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KMID : 0811820100140020166
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Journal of Korean Society of Pediatric Nephrology
2010 Volume.14 No. 2 p.166 ~ p.173
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Influence of VEGF Genetic Polymorphism on Peritoneal Solute Transport in Pediatric Dialysis Patients
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Choi Hyun-Jin
Paik Kyung-Hoon
Cho Hee-Yeon
Kang Hee-Gyung
Cheong Hae-Il
Choi Yong
Ha Il-Soo
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Abstract
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Purpose:Genetic and clinical factors can influence the permeability of the peritoneal membrane. The peritoneal equilibration test (PET) is helpful in measuring peritoneal permeability in peritoneal dialysis (PD). We investigated the influence of genetic polymorphism of vascular endothelial growth factor (VEGF) on the PET parameters.
Methods:Pediatric patients who underwent PET within 12 months of initiating PD at Seoul National University Children’s Hospital and Samsung Medical Center were selected. The patients with positive history of peritonitis before PET were excluded. The VEGF -2578C/ A, -14978T/C, -1154G/A, -634G/C, and +936C/T single-nucleotide polymorphisms were genotyped.
Results:The mean 4-hour dialysate-to-plasma ratio for creatinine (D/P creatinine) and the mean 4-hour dialysate glucose to baseline dialysate glucose ratio (D/D0 glucose) were 0.56±0.13 and 0.43±0.11, respectively. The patients with haplotype CTGGC showed higher 4-hour D/P creatinine (0.67±0.12 vs 0.50±0.09, P=0.007) and lower 4-hour D/D0 glucose (0.35±0.12 vs 0.47±0.08, P=0.037) than those without haplotype CTGGC.
Conclusion:The VEGF genetic polymorphism may influence the peritoneal solute transport.
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KEYWORD
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Peritoneal equilibration test, Vascular endothelial growth factor, Single nucleotide polymorphism, Peritoneal dialysis
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